Obesity, cause, treatment and complication

Low antibody levels within the body can cause a person susceptible to cardiovascular disease (heart and blood vessels), particularly stroke in men. Study published in Academic Journal of Atherosclerosis, directing the research to make immunization for cardiovascular disease.

Atherosclerosis (hardening of the arteries) is an inflammation of the blood vessel so that vessel walls become thickened and less elastic. It can cause blood clots and other heart diseases such as coronary heart disease. Until now it is not certain what causes atherosclerosis, but immune system is believed to have an important role. The researchers believe that levels of bad cholesterol, LDL (low-density lipoprotein) play a role in the development of this disease. The team of researchers from the Karolinska Institute in collaboration with Lund University, finds that there is a natural antibody called anti-PC, which has a target against LDL lipid molecules, play an important role in the development of cardiovascular disease.

Research suggests that individuals who have low levels of anti-PC have an increased risk for cardiovascular disease. Risk was further increased in men with stroke, nearly four times. Risk factors of low anti-PC stand alone and does not depend on other risk factors like high blood pressure, high cholesterol, and smoking.

“Our research to obtain data that anti-PC can be used to improve diagnosis and therapy. We are also developing anti-PC as a vaccine to prevent atherosclerosis and cardiovascular disease, “said Professor Johan Frostegard, chairman of the research.

The study involved 349 people who have a period of 12 years of heart attack or stroke and 693 individuals without symptoms of cardiovascular disease.

“Consumption of low-dose daily aspirin can help prevent recurrent heart attacks. But this would be risky if used on people who have never had a heart attack or stroke “, Drug and Therapeutics Bulletin reported.

Currently, approximately 50 million Americans consume low-dose aspirin (up to about 325 mg per day) to prevent heart problems and blood vessels. Some of them even do not have a history of heart attack or stroke (as primary prevention). This corresponds with recommendations from the American Diabetes Association (ADA), which states that consumption of low-dose aspirin can be used as primary prevention measures in diabetic patients who have heart disease risk and blood vessel (note that diabetes may increase the risk of developing heart disease dramatically) .

However, several recent studies indicate otherwise. There was not enough evidence to justify prescribing aspirin as primary prevention of heart disease. Benefit from the drug is not very meaningful, and konsumsinyapun not free from risks such as gastrointestinal bleeding (stomach, intestines) or stroke caused by bleeding, so the January 2010 recommendation suggested that the drug is only consumed by those who have a high risk.

Research Evidence
Although aspirin can thin blood and help prevent clots, consumption is still not free from risk, according to the UK review led by several experts.

For example, from two large studies conducted in each of 1.276 and 2.539 in diabetic patients, it can be concluded that those who consume 81-100 milligrams of aspirin per day had a risk of heart attack or stroke 4-7 years longer than those who do not consume aspirin. However, despite already having salute aimed at reducing gastric problems, those who take aspirin every day still have a risk two to four times more likely to contract gastrointestinal problems like ulcers (ulcus) with complications, compared with those not taking aspirin.

In addition, although able to prevent the formation of blood clots that can cause strokes in approximately 80% of people, aspirin can also boost the risk of haemorrhagic stroke, the cause of bleeding in the brain.

Without intending to scare, this article was created to show how many people are beginning to doubt and feel that the risk of aspirin daily consumption has exceeded the expected benefits to those who have never experienced a heart attack. So that aspirin is recommended only if its consumption can bring about greater benefits than risks that may be caused, namely those who had experienced heart attacks, bypass surgery, history of coronary artery blood vessel disease, or those who have no history of heart disease but classified as high risk heart disease, to those who have a bunch of heart disease risk factors, such as diabetes, smoking, high cholesterol and high blood pressure. Because once you have these conditions, then you will start to look like someone who had experienced a heart attack.

The point is there should be dialogue between patients and health practitioners about the benefits and risks of aspirin consumption. So, if you are currently taking aspirin, but not included in one of the criteria above, then you should immediately consult this with your doctor before continuing treatment. However, you should avoid the consumption of aspirin daily without the advice and supervision of a physician.